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Current projects

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This proof-of-concept randomized controlled clinical trial explores the safety, feasibility, and preliminary efficacy of psilocybin-enhanced psychotherapy versus treatment-as-usual among military Veterans being treated for methamphetamine use disorder within a residential treatment facility.

Funding: Steven & Alexandra Cohen Foundation; OHSU Foundation; study drug provided by Usona Institute
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The purpose of this multi-site randomized controlled trial is to evaluate the efficacy and risks of psilocybin for the treatment of depression in U.S. military Veterans with and without (±) concurrent posttraumatic stress disorder.

Funding: VA Office of Research & Development
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SNaP Lab is a site for this Phase 3, randomized, double-blind, multicenter study to evaluate the efficacy, safety, and tolerability of psilocybin in adults with Major Depressive Disorder (MDD).

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Many patients with chronic pelvic pain are not adequately helped by current treatments or may experience side effects. Emerging evidence suggests that psilocybin is effective in difficult-to-treat pain syndromes, such as migraines or cluster headaches. This study aims to assess the safety and feasibility of a single dose of psilocybin with supportive therapy to treat chronic pelvic pain and will be the first to evaluate psilocybin therapy for this condition. 

Additional Investigators: Lynne Shinto, ND & Jacq Knapp, MD; Funding: OHSU Women’s Health - Circle of Giving 
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OPEN is a nascent practice-based research network, designed to assess the safety and equity of psilocybin services in community-based settings and develop a framework for future studies. The OPEN project aims to collect confidential information from licensed psilocybin facilitators and their clients to assess their experience with legal psilocybin services.

Additional Investigators: Todd Korthuis, MD, MPH; Jason Luoma, PhD; Adie Rae, PhD
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© 2025 by Chris Stauffer, MD

The materials posted here do not represent the views of the U.S. Department of Veterans Affairs or the United States Government.

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